Short- and long-term changes in myocardial function, morphology, edema, and infarct mass after ST-segment elevation myocardial infarction evaluated by serial magnetic resonance imaging

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2007.06.038 Byline: Rasmus Sejersten Ripa (a)(b), Jens Christian Nilsson (c), Yongzhong Wang (a), Lars SA[cedilla]ndergaard (a), Erik JA[cedilla]rgensen (a), Jens Kastrup (a) Abstract: Knowledge of the natural course after an ST-elevation myocardial infarction (STEMI) treated according to guidelines is limited because comprehensive serial magnetic resonance imaging (MRI) of systolic left ventricular function, edema, perfusion, and infarct size after STEMI has not been undertaken. The aim of this study was to evaluate effects of therapy for STEMI on left ventricular function and perfusion and to test the hypothesis that myocardial perfusion by MRI predicts recovery of left ventricular function. Author Affiliation: (a) Department of Cardiology, The Heart Centre, University Hospital Rigshospitalet, Copenhagen, Denmark (b) Department of Radiology, University Hospital Rigshospitalet, Copenhagen, Denmark (c) Danish Research Centre for Magnetic Resonance, University Hospital Hvidovre, Hvidovre, Denmark Article History: Received 29 March 2007; Accepted 27 June 2007 Article Note: (footnote) The STEMMI trial has been funded with grants from the Danish Heart Foundation (no. 0442B18-A1322141); Danish Stem Cell Research Doctoral School; Faculty of Health Sciences, Copenhagen University; Lundbeck Foundation; Raimond og Dagmar RinggA[yen]rd-Bohn's Fond; Aase og Ejnar Danielsens Fond; Erik og Martha Scheibels Legat; Fonden af 17.12.1981; and Arvid Nilssons Fond.