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TLR4 activation mediates kidney ischemia/reperfusion injury

Authors :
Wu, Huiling
Chen, Gang
Wyburn, Kate R.
Yin, Jianlin
Bertolino, Patrick
Eris, Josette M.
Alexander, Stephen I.
Sharland, Alexandra F.
Chadban, Steven J.
Source :
Journal of Clinical Investigation. Oct, 2007, Vol. 117 Issue 10, p2847, 13 p.
Publication Year :
2007

Abstract

Ischemia/reperfusion injury (IRI) may activate innate immunity through the engagement of TLRs by endogenous ligands. TLR4 expressed within the kidney is a potential mediator of innate activation and inflammation. Using [...]

Subjects

Subjects :
Reperfusion injury -- Causes of
Reperfusion injury -- Genetic aspects
Reperfusion injury -- Research
Kidneys -- Transplantation
Kidneys -- Complications and side effects
Kidneys -- Research

Details

Language :
English
ISSN :
00219738
Volume :
117
Issue :
10
Database :
Gale General OneFile
Journal :
Journal of Clinical Investigation
Publication Type :
Academic Journal
Accession number :
edsgcl.170201363

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Authors Abstract Subjects Details