Synthesis of polysubstituted imidazo[1,2-a]pyridines via microwave-assisted one-pot cyclization/Suzuki coupling/palladium-catalyzed heteroarylation

A microwave-assisted one-pot, two-step or one-pot, three-step cylization/Suzuki/heteroarylation method was developed to synthesize the 2,3,6-trisubstituted imidazo[1,2-a]pyridine derivatives. The newly developed method could be applied to obtain other polysubstituted compounds from 2-amino-5-halogenopyridines, 2-halogenocarbonyl derivatives, boronic acids and heteroaryl bromides.