Platelet-derived growth factor triggers translocation of the insulin-regulatable glucose transporter (type 4) predominantly through phosphatidylinositol 3-kinase binding sites on the receptor

Translocation of glucose transporter type 4 (GLUT4) occurs in mammalian cells with the help of platelet-derived growth factor (PDGF)-stimulated activity of phosphatidylinositol (PI) 3-kinase. A study of mutant PDGF receptors confirm the role of PI3-kinase in GLUT4 translocation. In 3T3-L1 adipocytes and chinese hamster ovary cells that overexpress PDGF receptors, GLUT4 translocation is induced by PDGF and insulin.