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Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains

Authors :
Pravenec, Michal
Hyakukoku, Masaya
Houstek, Josef
Zidek, Vaclav
Landa, Vladimir
Mlejnek, Petr
Miksik, Ivan
Dudova-Mothejzikova, Kristyna
Pecina, Petr
Vrbacky, Marek
Drahota, Zdenek
Vojtiskova, Alena
Kazdova, Ludmila
Mracek, Tomas
Oliyarnyk, Olena
Ho, Christopher
Qi, Nathan
Ken Sugimoto
Jiaming Wang
Kurtz, Theodore
Source :
Genome Research. Sept, 2007, Vol. 17 Issue 9, 1319-1326
Publication Year :
2007

Abstract

The study results from conplastic strains of rat model which provide evidence linking naturally occurring variation in the mitochondrial genome, independent of variation in the nuclear genome and other confounding factors, to inherited variation in known risk factors for type 2 diabetes is presented.

Details

Language :
English
ISSN :
10889051
Volume :
17
Issue :
9
Database :
Gale General OneFile
Journal :
Genome Research
Publication Type :
Periodical
Accession number :
edsgcl.169003575