Relation between autoimmunity chronic urticaria and the levels of plasma prothrombin [F.sub.1+2]

A number of recent epidemiologic and experimental studies have enhanced our knowledge of the etiology and pathogenesis of chronic urticaria (CU), a disease that imposes profound impairment on patient's quality of life. Our study was performed to explore the relation between autoimmunity (CU) and the levels of plasma prothrombin [F.sub.1+2]. Thirty four (CU) patients with positive autologous serum skin test (APST) their [F.sub.1+2] were measured by ELISA at pre and post therapy. The levels of [F.sub.1+2] in autoimmunity (CU) patients have been decreased obviously After treatment (3.34[+ or -]2.87vs 0.94[+ or -]0.58, p0.05). Key words: chronic urticaria, [F.sub.1+2], Loratadine; dipyridamole
INTRODUCTION Chronic urticaria (CU) is defined by the almost daily presence of urticaria for at least 6 weeks without an identifiable cause. Symptoms include short-lived wheals, itching, and erythema. CU [...]