Extracellular matrix protein fibulin-2 is expressed in the embryonic endocardial cushion tissue and is a prominent component of valves in adult heart

Immunofluoresence studies reveal that fibulin-1 and -2 are significantly codistributed throughout the development of the endocardial cushion tissue (ECT) and are expressed in the heart valve in the adult stage. A comparative study suggests that fibulin-2 is a better marker than fibulin-1 for the ECT. ECT development and the tensile strength of the cardiac values are influenced by these two fibulins.