Lipoprotein (a) and Venous Thromboembolism in Adults: A Meta-Analysis

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.amjmed.2007.01.029 Byline: Francesco Sofi (a), Rossella Marcucci (a), Rosanna Abbate (a), Gian Franco Gensini (a)(b), Domenico Prisco (a) Keywords: Deep venous thrombosis; Lipoprotein (a); Meta-analysis; Venous thromboembolism Abstract: Lipoprotein (a) [Lp(a)], a low-density lipoprotein particle linked to apolipoprotein (a), has been recently demonstrated to be an independent risk factor for arterial vascular diseases. However, despite increasing evidence of the association between high Lp(a) and arterial thrombotic diseases, few and conflicting results on the association between high Lp(a) levels and venous thromboembolism have been obtained. The aim of this article is to systematically examine the published data on the association between high Lp(a) levels and venous thromboembolism. Author Affiliation: (a) Department of Medical and Surgical Critical Care, Thrombosis Centre; Centre for the study at molecular and clinical level of chronic, degenerative and neoplastic diseases to DEvelop NOvel THErapies, University of Florence, Italy (b) Don Carlo Gnocchi Foundation, Centro S. Maria agli Ulivi, Onlus IRCCS, Florence; Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.