A Fight for Neurotransmission: SCRAPPER Trashes RIM

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.cell.2007.08.020 Byline: Frederick Dobie (1), Ann Marie Craig (1) Abstract: The presynaptic scaffold molecule RIM1[alpha] is important for regulating neurotransmitter release. In this issue, show in mice that an E3 ubiquitin ligase, SCRAPPER, targets a set of presynaptic proteins including RIM1[alpha] for degradation by the ubiquitin-proteasome system. Their results identify protein degradation as a mechanism for holding rapid synaptic communication in check. Author Affiliation: (1) Brain Research Centre and Department of Psychiatry, University of British Columbia, Vancouver, BC, V6T 2B5, Canada