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Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain

Authors :
DiSanto, James P.
Muller, Werner
Guy-Grand, Delphine
Fischer, Alain
Rajewsky, Klaus
Source :
Proceedings of the National Academy of Sciences of the United States. Jan 17, 1995, Vol. 92 Issue 2, p377, 5 p.
Publication Year :
1995

Abstract

A study of mice obtained from embryonic stem (ES) cells mutated at the interleukin 2 receptor gamma chain (IL-2Rgamma) by Cre loxP-mediated recombination shows that IL-2Rgamma mediates the production and activity of mainstream B- and T-cells and also contributes to natural killer (NK)-cell development. The mutant mice deficient in IL-2R gamma show reduced levels of B, T and NK cells. Mutation also attenuates gut-associated intraepithelial lymphocytes and abolishes the Peyer's patches.

Details

ISSN :
00278424
Volume :
92
Issue :
2
Database :
Gale General OneFile
Journal :
Proceedings of the National Academy of Sciences of the United States
Publication Type :
Academic Journal
Accession number :
edsgcl.16774391