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Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain
- Source :
- Proceedings of the National Academy of Sciences of the United States. Jan 17, 1995, Vol. 92 Issue 2, p377, 5 p.
- Publication Year :
- 1995
-
Abstract
- A study of mice obtained from embryonic stem (ES) cells mutated at the interleukin 2 receptor gamma chain (IL-2Rgamma) by Cre loxP-mediated recombination shows that IL-2Rgamma mediates the production and activity of mainstream B- and T-cells and also contributes to natural killer (NK)-cell development. The mutant mice deficient in IL-2R gamma show reduced levels of B, T and NK cells. Mutation also attenuates gut-associated intraepithelial lymphocytes and abolishes the Peyer's patches.
Details
- ISSN :
- 00278424
- Volume :
- 92
- Issue :
- 2
- Database :
- Gale General OneFile
- Journal :
- Proceedings of the National Academy of Sciences of the United States
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.16774391