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The P-Glycoprotein (ABCB1) linker domain encodes high-affinity binding sequences to [alpha]- and [beta]-tubulins

Authors :
Georges, Elias
Source :
Biochemistry. June 26, 2007, Vol. 46 Issue 25, p7337, 6 p.
Publication Year :
2007

Abstract

The P-Glycoprotein (ABCB1) is a linker domain that causes multidrug resistance in tumor cells selected with lipophilic anticancer drugs. ABCB1 helps in encoding high-affinity binding sequences to [alpha]- and [beta]-tubulins and hence can be used in various tumor cells.

Details

Language :
English
ISSN :
00062960
Volume :
46
Issue :
25
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.167546681