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Structure and mechanism of the 6-deoxyerythronolide B synthase

Authors :
Khosla, Chaitan
Yinyan Tang
Chen, Alice Y.
Schnarr, Nathan A.
Cane, David E.
Source :
Annual Review of Biochemistry. Annual, 2006, Vol. 76, p195, 27 p.
Publication Year :
2006

Abstract

The synthesis of 6-deoxyerythronolide B, the macrocyclic aglycone of the antibiotic erythromycin by a polyketide synthase (PKS) that has emerged as the prototypical modular megasynthase is described.

Details

Language :
English
ISSN :
00664154
Volume :
76
Database :
Gale General OneFile
Journal :
Annual Review of Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.167194257