Interaction between angiotensin II and nitric oxide in control of renal hemodynamics in conscious dogs

A study of the effects on renal excretion and hemodynamics confirms that nitric oxide regulates the renal vasoconstrictor effects of angiotensin II (ANG II). NO synthesis inhibition within the kidney through intrarenal L-NAME administration improves the renal hemodynamic effects of ANG II and reduces the glomerular filtration rate. NO synthesis blockade improves the effect of ANG II on sodium excretion in a dose-dependent-manner, due to the significant decrease in glomerular filtration rate and filtered sodium load.