An ab initio investigation of the interactions involving the aromatic group of the set of fluorinated N-(4-sulfamylbenzoyl) benzylamine inhibitors and human carbonic anhydrase II

Authors :: Riley, Kevin E.
Guanglei Cui
Merz, Kenneth M.
Source :: Journal of Physical Chemistry B. May 24, 2007, Vol. 111 Issue 20, p5700, 8 p.
Publication Year :: 2007
Abstract: The interactions between the aromatic portion of the fluorinated n-(4-sulfamylbenzoyl)benzylamine (SBB) inhibitors and two residues of Human Carbonic Anhydrase II (HCAII)- Phe-131 and Pro-202 are studied. The structure of proteins is determined by the interactions between aromatic rings.

Subjects :: Carbonic anhydrase inhibitors -- Chemical properties
Sulfur compounds -- Chemical properties
Fluorine compounds -- Chemical properties
Aromatic compounds -- Chemical properties
Chemicals, plastics and rubber industries

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