Effect of ouabain on pressor responsiveness in normal man

Short term ouabain treatment does not change the plasma concentration of vasoactive hormones or pressor responsivesness in healthy males. Ouabain treatment decreases heart rate and enhances pulse pressure, but has no influence on pressor responsiveness to either norepinephrine or angiotensin II. Ouabain also does not influence the circulating quantities of renin, epinephrine norepinephrine, aldosterone, angiotensin II, brain natriuretic peptide and atrial natriuretic peptide.