Role of Kupffer cells in the pathogenesis of hepatic reperfusion injury

Authors :: Bremer, Christoph
Bradford, Blair U.
Hunt, Kelly J.
Knecht, Kathy T.
Connor, Henry D.
Mason, Ronald P.
Thurman, Ronald G.
Source :: The American Journal of Physiology. Oct, 1994, Vol. 267 Issue 4, pG630, 7 p.
Publication Year :: 1994
Abstract: Experimental studies of the inactivation of Kupffer cells by GdCl3 reveal the vital role of Kupffer cell activation in the pathogenesis of hepatic reperfusion injury. Lactate dehydrogenase (LDH) and malondialdehyde (MDA) release and oxygen uptake reach a maximum within the first 10 minutes of reperfusion. Inactivation of Kupffer cells by GdCl3 decreases the release of LDH and MDA. Electron paramagnetic resonance spectroscopic studies reveal the involvement of a carbon-centered radical during reflow and that GdCl3 inhibits the formation of the radical.