GILZ mediates the antiproliferative activity of glucocorticoids by negative regulation of Ras signaling

Authors :: Ayroldi, Emira
Zollo, Ornella
Bastianelli, Alessandra
Marchetti, Cristina
Agostini, Massimiliano
Di Virgilio, Rosa
Riccardi, Carlo
Source :: Journal of Clinical Investigation. June, 2007, Vol. 117 Issue 6, p1605, 11 p.
Publication Year :: 2007
Abstract: Tsc22d3 coding for glucocorticoid-induced leucine zipper (GILZ) was initially identified as a dexamethasone-responsive gene involved in the control of T lymphocyte activation and apoptosis. However, the physiological role of this [...]

Subjects :: Corticosteroids -- Research
Ras genes -- Research
Genetic regulation -- Research

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