Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID)

Authors :: Garibyan, Lilit
Lobito, Adrian A.
Siegel, Richard M.
Call, Matthew E.
Wucherpfennig, Kai W.
Geha, Raif S.
Source :: Journal of Clinical Investigation. June, 2007, Vol. 117 Issue 6, p1550, 8 p.
Publication Year :: 2007
Abstract: B cells from patients with common variable immunodeficiency (CVID) who are heterozygous for transmembrane activator and CAML interactor (TACI) mutation C104R, which abolishes ligand binding, fail to produce Igs in [...]

Subjects :: B cells -- Research
Cell receptors -- Research
Haploidy -- Research
Heterozygosis -- Research
Immunological deficiency syndromes -- Research

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