Interaction of product analogues with the active site of Rhodobacter sphaeroides dimethyl sulfoxide reductase

The structural characterization of Rhodobacter sphaeroides dimethyl sulfoxide (DMSO) reductase reduced with trimethylarsine is presented and shown that it is structurally analogous to the physiologically relevant dimethyl sulfide reduced DMSO reductase. The similarity of the trimethylarsine and dimethyl sulfide complexes has indicated that the dimethyl sulfide reduced enzyme consists of a classical coordination of DMSO with no special elongation of the S-O bond.