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DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans
- Source :
- Genetics. April, 2007, Vol. 175 Issue 4, p1719, 15 p.
- Publication Year :
- 2007
-
Abstract
- The genes egl-1, ced-9, ced-4, and ced-3 play major roles in programmed cell death in Caenorhabditis elegans. To identify genes that have more subtle activities, we sought mutations that confer strong cell-death defects in a genetically sensitized mutant background. Specifically, we screened for mutations that enhance the cell-death defects caused by a partial loss-of-function allele of the ced-3 caspase gene. We identified mutations in two genes not previously known to affect cell death, dpl-1 and mcd-1 (modifier of cell death), dpl-1 encodes the C. elegans homolog of DP, the human E2F-heterodimerization partner. By testing genes known to interact with dpl-1, we identified roles in cell death for four additional genes: eft-1 E2F, lin-35 Rb, lin-37 Mip40, and lin-52 dLin52, mcd-1 encodes a novel protein that contains one zinc finger and that is synthetically required with lin-35 Rb for animal viability, dpl-1 and mcd-1 act with eft-1 E2F and lin-35 Rb to promote programmed cell death and do so by regulating the killing process rather than by affecting the decision between survival and death. We propose that the DPL-1 DP, MCD-1 zinc finger, EFL-1 E2F, LIN-35 Rb, LIN-37 Mip40, and LIN-52 dLin52 proteins act together in transcriptional regulation to promote programmed cell death.
Details
- Language :
- English
- ISSN :
- 00166731
- Volume :
- 175
- Issue :
- 4
- Database :
- Gale General OneFile
- Journal :
- Genetics
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.164523723