A genome-wide search for human type 1 diabetes susceptibility genes

Authors :: Davies, June L.
Kawaguchi, Yoshihiko
Bennett, Simon T.
Copeman, James B.
Cordell, Heather J.
Pritchard, Lynn E.
Reed, Peter W.
Gough, Stephen C.L.
Jenkins, Suzanne C.
Palmer, Sheila M.
Balfour, Karen M.
Rowe, Beth R.
Farrall, Martin
Barnett, Anthony H.
Bain, Stephen C.
Todd, John A.
Source :: Nature. Sept 8, 1994, Vol. 371 Issue 6493, p130, 7 p.
Publication Year :: 1994
Abstract: Polymerase chain reaction, high-resolution human genetic linkage maps and automated DNA fragment-sizing strategy help conduct a human genome-wide search for type 1 diabetes susceptibility genes. IDDM1, IDDM2 and eighteen other chromosomal sites are found to be associated with diabetes mellitus. Chromosomes 11q and 6q express the genes IDDM4 and IDDM5 genes respectively.