Oxidized cholesterol metabolites found in human atherosclerotic lesions promote apolipoprotein C-II amyloid fibril formation

A study is conducted to show that the primary ozonolysis product of cholesterol, 3[beta]-hydroxy-5-oxo-5,6-secocholestan-6-al(KA) rapidly promotes human apolipoprotein (apo)C-II amyloid fibril formation in vitro. During the study KA randomly modified six different lysine residues with primarily one KA attached per apoC-II molecule.