The univin gene encodes a member of the transforming growth factor-beta superfamily with restricted expression in the sea urchin embryo

PCR cloning, library screening and RNA blotting procedures reveal a new gene univin, encoding the transformation growth factor beta (TGF-beta) and belonging to the bone morphogenetic protein group in the sea urchin Stronglyocentrotus purpuratus. The cDNA clone of the gene contains a 383-amino acid residue protein with seven cysteine residues and a cluster of basic residues. The spatial and temporal patterns of the gene vary at different developmental stages and are similar to those of SpAN gene, suggesting a correlation between SpAN and univin in regulating developmental stages in sea urchin embryo.