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Role of protons in the thermodynamic contribution of a Zn(II)-Cy[S.sub.4] site toward metalloprotein stability

Role of protons in the thermodynamic contribution of a Zn(II)-Cy[S.sub.4] site toward metalloprotein stability

Authors :
Reddi, Amit R.
Gibney, Brian R.
Source :
Biochemistry. March 27, 2007, Vol. 46 Issue 12, p3745, 14 p.
Publication Year :
2007

Abstract

The reaction of [[Zn(II)[[[H.sub.2]O].sub.6]].sup.2+] with a minimal, unstructured, tetracysteine 16-mer peptide, GGG is described to elucidate the thermodynamic contribution of a Zn(II)-[(S.Cys).sub.4] site toward metalloprotein stability relevant to classic structural Zn(II) sites. It is demonstrated that the entropy driven binding of Zn(II) reflects the proton dependent chemical speciation of the Zn(II)-[(S.Cys).sub.4] peptide complex.

Details

Language :
English
ISSN :
00062960
Volume :
46
Issue :
12
Database :
Gale General OneFile
Journal :
Biochemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.163321976