Identification of a novel risk locus for progressive supranuclear palsy by a pooled genomewide scan of 500,288 single-nucleotide polymorphisms

Authors :: Melquist, Stacey
Craig, David W.
Huentelman, Matthew J.
Crook, Richard
Pearson, John V.
Baker, Matt
Zismann, Victoria L.
Gass, Jennifer
Adamson, Jennifer
Szelinger, Szabolcs
Corneveaux, Jason
Cannon, Ashley
Coon, Keith D.
Lincoln, Sarah
Adler, Charles
Tuite, Paul
Calne, Donald B.
Bigio, Eileen H.
Uitti, Ryan J.
Wszolek, Zbigniew K.
Golbe, Lawrence I.
Caselli, Richard J.
Graff-Radford, Neill
Litvan, Irene
Farrer, Matthew J.
Dickson, Dennis W.
Hutton, Mike
Stephan, Dietrich A.
Source :: American Journal of Human Genetics. April, 2007, Vol. 80 Issue 4, p769, 9 p.
Publication Year :: 2007
Abstract: A hypothesis that additional genetic loci might be involved in conferring risk of progressive supranuclear palsy (PSP) that could be identified through a pooling-based genomewide association study of >500,000 SNPs is presented. Ranking all SNPs by their probe-intensity difference between cohorts identifies candidate SNPs with large differences in alleic frequency.

Subjects :: Single nucleotide polymorphisms -- Research
Progressive supranuclear palsy -- Genetic aspects
Biological sciences

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