Covalent catalysis by pyridoxal: Evaluation of the effect of the cofactor on the carbon acidity of glycine

A study determines the first-order rate constants for deprotonation of the [alpha]-amino carbon of the adduct between 5'-deoxypyridoxal and glycine. No significant deprotonation is found at pH 7.1 of the form of the 1-glycine iminium ion with the pyridine nitrogen in the basic form.