Effects of hydrogen-bonding and stacking interactions with amino acids on the acidity of uracil

The density functional theory is employed to study and explain the various effects of the hydrogen-bonding and stacking interactions with amino acids on the acidity of uracil, which depends on the nature of amino acid and binding orientation. The results show that such interactions decrease the gas-phase acidity of uracil, which also varies with the nature of the molecule bound, as well as the binding orientations and strengths.