Cardiac Troponin I in Fulminant Adenovirus Myocarditis Treated with a 24-Hour Infusion of High-Dose Intravenous Immunoglobulin

Byline: G. Briassoulis (1), G. Papadopoulos (2), N. Zavras (1), V. Pailopoulos (2), T. Hatzis (1), V. Thanopoulos (2) Keywords: Key words: Myocarditis -- Troponins -- Adenovirus -- Immunoglobulin Abstract: We report a successful outcome on an acute adenovirus myocarditis treated with a 24-hour high-dose intravenous immunoglobulin (24-HDIVIG) in a 4.5-year-old girl. A postviral etiology of acute myocarditis was assessed on the basis of the polymerase chain reaction technique. Among other early markers of cardiac injury, cardiac isoform of troponin-I (cTnI) was significantly correlated to the left ventricular ejection fraction (r=-0.86, p &lt 0.0001). Follow-up of cTnI, which might also be correlated to the short-term outcome, allows fast, easy, and noninvasive estimation of response to the aggressive treatment with 24-HDIVIG in acute adenovirus myocarditis in children. Author Affiliation: (1) Pediatric Intensive Care Unit, ``Aghia Sophia'' Children's Hospital, Levadias &amp Thivon Street, Athens, Greece, GR (2) Department of Pediatric Cardiology, ``Aghia Sophia'' Children's Hospital, Levadias &amp Thivon Street, Athens Greece, GR