Ulcerative colitis in a renal transplant patient with previous Goodpasture disease

Byline: Anna Maria Hibbs (1), Bojana Bznik-Cizman (2), Martha Guttenberg (3), Beth Goldberg (1), K. Meyers (1) Keywords: KeywordsaAnti-GBM disease; Cytomegalovirus; Ulcerative colitis; HLA Abstract: A renal transplant was performed in a 6-year-old boy who developed end stage renal disease (ESRD) after presenting with antiglomerular basement membrane (anti-GBM) disease. At 10 years of age he developed ulcerative colitis while being immunosuppressed with cyclosporin, prednisone, and azothioprine. He had a pancolectomy, and at 14 years has no symptoms of ulcerative colitis or anti-GBM disease. HLA typing revealed that he was homozygous for HLA DR2. The co-occurrence of anti-GBM disease and ulcerative colitis has not previously been described. Although there is no known common etiology for these two autoimmune diseases, we propose that the patient's homozygosity at HLA DR2 may have predisposed him to both. Author Affiliation: (1) Division of Nephrology, The Children's Hospital of Philadelphia, 34th St. and Civic Center Blvd., Philadelphia, PA 19104, and the University of Pennsylvania Medical School, Philadelphia, PA 19104-4399, USA e-mail: meyersk@email.chop.edu Tel.: +1-215-5902449, Fax: +1-215-5903705, US (2) Department of Immunology and Infectious Diseases, The Children's Hospital of Philadelphia, 34th St. and Civic Center Blvd., Philadelphia, PA 19104, and the University of Pennsylvania Medical School, Philadelphia, PA 19104, USA, US (3) Department of Pathology, The Children's Hospital of Philadelphia, 34th St. and Civic Center Blvd., Philadelphia, PA 19104, and the University of Pennsylvania Medical School, Philadelphia, PA 19104, USA, US Article note: Received: 21 September 2000 / Revised: 26 January 2001 / Accepted: 1 February 2001