Physicochemical Parameters of the Blood Serum and Renal Function in Children with Some Internal Diseases

Byline: A. A. Kuznetsova (1), Yu. V. Natochin (2) Abstract: The blood serum osmolality and ion concentrations were studied in 144 children (healthy or having some diseases), and no deviations from the universally accepted normal values were found. Although the mean values were in the normal range, the diseases were associated with an increased variation of serum osmolality and ion concentrations, indicating an imbalance of the regulatory system. Normally, human urine is hyperosmolal and the urination depends on the excretion of osmotically active substances. This determines a physiological paradox: an increase in diuresis is accompanied by a concurrent increase in reabsorption of osmotically free water. Author Affiliation: (1) St. Petersburg State Pediatric Medical Academy, St. Petersburg, 194000, Russia (2) Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, 194223, Russia Article History: Registration Date: 06/10/2004