Structure of human rhinovirus 3C protease reveals a trypsin-like polypeptide fold, RNA-binding site, and means for cleaving precursor polyprotein

The structure of human rhinovirus-14 3C protease (3Cpro) discloses folds constituting two topologically equivalent six-stranded beta barrels and suggests means for 3CD polyprotein cleavage. Functions of 3Cpro include providing a binding site for RNA binding with catalytic residues. 3Cpro is akin to trypsin-like serine protease in forming folds.