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The anti-amyloidogenic effect is exerted against Alzheimer's [beta]-amyloid fibrils in vitro by preferential and reversible binding of flavonoids to the amyloid fibril structure
- Source :
- Biochemistry. Feb 20, 2007, Vol. 46 Issue 7, p1888, 12 p.
- Publication Year :
- 2007
-
Abstract
- Various methodologies including spectrophotometry, spectrofluorometry and surface plasmon resonance (SPR) are used to study the formation of Alzheimer's [beta]-amyloid fibrils (fA[beta]) by various anti-amyloidogenic compounds. The in vitro experiments reveal that flavonoids inhibit a preferential and reversible binding to the amyloid fibril structure of fA[beta], which leads to the amyloidogenic effect against the fibrils.
- Subjects :
- Amyloid beta-protein -- Structure
Amyloid beta-protein -- Research
Bioflavonoids -- Structure
Bioflavonoids -- Chemical properties
Flavones -- Structure
Flavones -- Chemical properties
Flavonoids -- Structure
Flavonoids -- Chemical properties
Alzheimer's disease -- Research
Polyacrylamide -- Structure
Polyacrylamide -- Chemical properties
Biological sciences
Chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 46
- Issue :
- 7
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.161230841