Selection of multiple human immunodeficiency virus type 1 variants that encode viral proteases with decreased sensitivity to an inhibitor of the viral protease

Human immunodeficiency virus type 1 (HIV-1) variants produced under selective pressure encode low-sensitivity viral proteases to viral protease inhibitors. The protease interacts with the inhibitor and induces alterations in the three subsites of the proteases. HIV-1 potentially alters multiple inhibitor residues to change the protease-inhibitor interactions with variable specificities.