Activation of JAK2 tyrosine kinase by prolactin receptors in Nb2 cells and mouse mammary gland explants

Authors :: Campbell, George S.
Argetsinger, Lawrence S.
Ihle, James N.
Kelly, Paul A.
Rillema, James A.
Carter-Su, Christin
Source :: Proceedings of the National Academy of Sciences of the United States. June 7, 1994, Vol. 91 Issue 12, p5232, 5 p.
Publication Year :: 1994
Abstract: An immunological analysis of Nb2 cells and mouse mammary gland explants suggests that JAK2, present in Nb2 cells and gland explants, is a prolactin (PRL) receptor-related tyrosine kinase which is induced upon ligand binding to PRL receptor. JAK2 acts as a signal mediator for other cytokine/hematopoietin receptors and indicates that these receptors share signaling pathways. JAK2 activation requires the formation of a receptor-JAK2 complex and a ligand-dependent event.

Subjects :: Prolactin -- Research
Mammary glands -- Research
Ligand binding (Biochemistry) -- Research
Science and technology

ISSN :: 00278424
Volume :: 91
Issue :: 12
Database :: Gale General OneFile
Journal :: Proceedings of the National Academy of Sciences of the United States
Publication Type :: Academic Journal
Accession number :: edsgcl.16116646

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