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Synthetic fibronectin peptides interrupt inflammatory cell infiltration in transforming growth factor beta1 knockout mice
- Source :
- Proceedings of the National Academy of Sciences of the United States. May 24, 1994, Vol. 91 Issue 11, p5187, 5 p.
- Publication Year :
- 1994
-
Abstract
- Heparin- and cell-binding sequences of fibronectin peptides (FN) induced in transforming growth factor beta1 (TGF-beta1) prevents adhesion of leukocytes to vascular endothelial cells and eliminates cardiopulmonary and inflammation diseases in mice. The FN peptides react with cell surface proteoglycans and integrins of beta1 complex to reduce infiltration of inflammatory cells into heart and lungs of TGF-beta1 injected mice.
Details
- ISSN :
- 00278424
- Volume :
- 91
- Issue :
- 11
- Database :
- Gale General OneFile
- Journal :
- Proceedings of the National Academy of Sciences of the United States
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.16083746