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Localization of inositol trisphosphate receptor subtype 3 to insulin and somatostatin secretory granules and regulation of expression in islets and insulinoma cells
- Source :
- Proceedings of the National Academy of Sciences of the United States. August 2, 1994, Vol. 91 Issue 16, p7777, 5 p.
- Publication Year :
- 1994
-
Abstract
- Immunocytochemistry proves the expression of inositol 1,4,5-trisphosphate receptor subtype 3 (IP3R-3) in pancreatic islets. Immunogold electron microscopy helps localize these cells to the secretory granules of insulin-secreting beta cells and somatostatin secretory granules. Localization studies reveal the involvement of granule Ca(2+) stores in the secretory process, which is regulated by IP3R-3. Diabetes and fasting or refeeding increases IP3R-3 levels in islets and glucose increases IP3R-3 levels in insulinoma cells.
Details
- ISSN :
- 00278424
- Volume :
- 91
- Issue :
- 16
- Database :
- Gale General OneFile
- Journal :
- Proceedings of the National Academy of Sciences of the United States
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.16078039