Protein kinases C-beta and C-epsilon link the mast cell high-affinity receptor for IgE to the expression of c-fos and c-jun

Authors :: Razin, Ehud
Szallasi, Zoltan
Kazanietz, Marcelo G.
Blumberg, Peter M.
Rivera, Juan
Source :: Proceedings of the National Academy of Sciences of the United States. August 2, 1994, Vol. 91 Issue 16, p7722, 5 p.
Publication Year :: 1994
Abstract: Two isozymes of protein kinase C (PKC), PKC-beta and -epsilon, participate in c-fos and C-jun mRNA accumulation in the rat basophilic leukemia cell line, RBL-2H3. Aggregation of high-affinity IgE receptors has no influence on induction of c-fos and c-jun at high strengths of PKC-beta and -epsilon. Aggregation influences induction at low concentrations. PKC-beta and -epsilon connects the cell surface receptor and gene expression.

Subjects :: Protein kinases -- Research
Gene expression -- Analysis
Cellular signal transduction -- Analysis
Immunoglobulin E -- Analysis
Science and technology

ISSN :: 00278424
Volume :: 91
Issue :: 16
Database :: Gale General OneFile
Journal :: Proceedings of the National Academy of Sciences of the United States
Publication Type :: Academic Journal
Accession number :: edsgcl.16078017

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