Circadian clock locus frequency: protein encoded by a single open reading frame defines period length and temperature compensation

Authors :: Aronson, Benjamin D.
Johnson, Keith A.
Dunlap, Jay C.
Source :: Proceedings of the National Academy of Sciences of the United States. August 2, 1994, Vol. 91 Issue 16, p7683, 5 p.
Publication Year :: 1994
Abstract: Molecular characterization of frequency locus (frq) reveals two transcripts mapped to this region and a third transcript. The 989-amino acid FRQ protein influences generation of circadian rhythms and stabilizes these rhythms against different environmental conditions. Removal of an open reading frame (ORF) causes loss of rhythm stability and compensation, suggesting the role of this single ORF in changing period length and temperature compensation. FRQ dictates the functioning of the Neurospora circadian clock assembly.

Subjects :: Circadian rhythms -- Research
Genetic transcription -- Regulation
Science and technology

ISSN :: 00278424
Volume :: 91
Issue :: 16
Database :: Gale General OneFile
Journal :: Proceedings of the National Academy of Sciences of the United States
Publication Type :: Academic Journal
Accession number :: edsgcl.16078001

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