High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2

Authors :: Pierantoni, Giovanna Maria
Rinaldo, Cinzia
Mottolese, Marcella
Benedetto, Anna Di
Esposito, Francesco
Soddu, Silvia
Fusco, Alfredo
Source :: Journal of Clinical Investigation. March, 2007, Vol. 117 Issue 3, p693, 10 p.
Publication Year :: 2007
Abstract: High-mobility group A1 (HMGA1) overexpression and gene rearrangement are frequent events in human cancer, but the molecular basis of HMGA1 oncogenic activity remains unclear. Here we describe a mechanism through [...]

Subjects :: Antibody diversity -- Research
Protein kinases -- Research
Proteins -- Research
Chromosomes
Cytoplasm

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