Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition

Authors :: Meyer-Lindenberg, Andreas
Straub, Richard E.
Lipska, Barbara K.
Verchinski, Beth A.
Goldberg, Terry
Callicott, Joseph H.
Egan, Michael F.
Huffaker, Stephen S.
Mattay, Venkata S.
Kolachana, Bhaskar
Kleinman, Joel E.
Weinberger, Daniel R.
Source :: Journal of Clinical Investigation. March, 2007, Vol. 117 Issue 3, p672, 11 p.
Publication Year :: 2007
Abstract: Dopamine- and cAMP-regulated phosphoprotein of molecular weight 32 kDa (DARPP-32), encoded by PPP1R1B, is a pivotal integrator of information in dopaminoceptive neurons, regulating the response to neuroleptics, psychotomimetics, and drugs [...]

Subjects :: Molecular weights -- Case studies
Neurons -- Genetic aspects
Neurons -- Case studies
Cardiac glycosides
Cardiotonic agents
Cognition
Dopamine
Phosphoproteins

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