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APL-1, a Caenorhabditis elegans protein related to the human [beta]-amyloid precursor protein, is essential for viability
- Source :
- Proceedings of the National Academy of Sciences of the United States. Feb 6, 2007, Vol. 104 Issue 6, p1971, 6 p.
- Publication Year :
- 2007
-
Abstract
- Dominant mutations in the amyloid precursor protein (APP) gene are associated with rare cases of familial Alzheimer's disease; however, the normal functions of APP and related proteins remain unclear. The nematode Caenorhabditis elegans has a single APP-related gene, apl-1, that is expressed in multiple tissues. Loss of apl-1 disrupts several developmental processes, including molting and morphogenesis, and results in larval lethality. The apl-1 lethality can be rescued by neuronal expression of the extracellular domain of APL-1. These data highlight the importance of the extracellular domain of an APP family member and suggest that APL-1 acts noncell-autonomously during development. Overexpression of APL-1 also causes several defects, including a high level of larval lethality. Decreased activity of sel-12, a C elegans homologue of the human [gamma]-secretase component presenilin 1, partially rescues the lethality associated with APL-1 overexpression, suggesting that SEL-12 activity regulates APL-1 activity either directly or indirectly. Alzheimer's disease | genetics | model system
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 104
- Issue :
- 6
- Database :
- Gale General OneFile
- Journal :
- Proceedings of the National Academy of Sciences of the United States
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.159785442