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Muscle cachexia is regulated by a p53-PW1/Peg3-dependent pathway
- Source :
- Genes & Development. Dec 15, 2006, Vol. 20 Issue 24, p3440, 13 p.
- Publication Year :
- 2006
-
Abstract
- The tumor necrosis factor-[alpha] (TNF[alpha])-mediated inhibition of myogenic differentiation is found to be dependent on p53 through a PW1-mediated pathway. The p53 plays a novel role in mediating muscle stem cell behavior and muscle atrophy, and has pointed towards new targets for the therapeutic treatment of muscle wasting (cachexia).
Details
- Language :
- English
- ISSN :
- 08909369
- Volume :
- 20
- Issue :
- 24
- Database :
- Gale General OneFile
- Journal :
- Genes & Development
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.158940662