fac-{Ru[(CO).sub.3]}.sup.2.plus -core complexes and design of metal-based drugs: Synthesis, structure, and reactivity of Ru-thiazole derivative with serum proteins and absorption-release studies with acryloyl and silica hydrogels as carriers in physiological media

An efficient one-step synthesis of fac-[Ru[(CO).sub.3][Cl.sub.2](THZ)] (THZ = 1,3-thiazole) from commercial [[Ru[(CO).sub.3][Cl.sub.2]].sub.2] is described. The reactivity of fac-[Ru[(CO).sub.3]C[l.sub.2](THZ)] with biomolecules and synthetic hydrogels makes it a compound of interest for anticancer and antimetastases tests.