Photoinduced intramolecular electron-transfer reactions for reconstituted met-and zinc-myoglobins appending acridine and methylacridinium ion as DNA binders

The synthesis of three types of met- and zinc- myoglobin dyads, ZnMbAc(4)[Me.sup.+], ZnMbAc(6)[Me.sup.+], and metMbAc(6) is described by incorporating chemically modified metalloporphyrin cofactor appending an acridine(Ac) or a methylacridium ion ([[AcMe].sup.+]) into apo-Mb. It is shown that synthetic manipulation at the Mb surface with the use of an artificial DNA binder along with photoinduced reaction, can give insight to build new Mb-DNA complex and sensitive fluorescent for DNA.