Back to Search
Start Over
Crystal structure and DNA interaction of the facial-type rac-Tris[2-(aminomethyl)benzimidazole]cobalt(III) complex
Crystal structure and DNA interaction of the facial-type rac-Tris[2-(aminomethyl)benzimidazole]cobalt(III) complex
- Source :
- Inorganic Chemistry. Dec 11, 2006, Vol. 45 Issue 25, p10031, 3 p.
- Publication Year :
- 2006
-
Abstract
- The crystal structure and DNA interaction of the tris-chelate Co(III) complex fac-[Co[(ambi).sub.3]][Cl.sub.3]*3[H.sub.2]O which could be exploited to counteract DNA condensation uniquely arising from electrostatic force in the presence of multivalent [[Co[(ambi).sub.3]].sup.3+] is reported. Results reveal that the metal q/r ratio and ring functionality could be exploited to modulate the binding affinities of multivalent complexes, thereby offering potential applications in chemotherapy against cancer and careful control of the DNA condensation reaction in gene therapy.
Details
- Language :
- English
- ISSN :
- 00201669
- Volume :
- 45
- Issue :
- 25
- Database :
- Gale General OneFile
- Journal :
- Inorganic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.158134226