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Crystal structure and DNA interaction of the facial-type rac-Tris[2-(aminomethyl)benzimidazole]cobalt(III) complex

Crystal structure and DNA interaction of the facial-type rac-Tris[2-(aminomethyl)benzimidazole]cobalt(III) complex

Authors :
Gomez-Segura, Jordi
Prieto, Maria Jose
Font-Bardia, Merce
Solans, Xavier
Moreno, Virtudes
Source :
Inorganic Chemistry. Dec 11, 2006, Vol. 45 Issue 25, p10031, 3 p.
Publication Year :
2006

Abstract

The crystal structure and DNA interaction of the tris-chelate Co(III) complex fac-[Co[(ambi).sub.3]][Cl.sub.3]*3[H.sub.2]O which could be exploited to counteract DNA condensation uniquely arising from electrostatic force in the presence of multivalent [[Co[(ambi).sub.3]].sup.3+] is reported. Results reveal that the metal q/r ratio and ring functionality could be exploited to modulate the binding affinities of multivalent complexes, thereby offering potential applications in chemotherapy against cancer and careful control of the DNA condensation reaction in gene therapy.

Details

Language :
English
ISSN :
00201669
Volume :
45
Issue :
25
Database :
Gale General OneFile
Journal :
Inorganic Chemistry
Publication Type :
Academic Journal
Accession number :
edsgcl.158134226