Endotoxic shock in AUF1 knockout mice mediated by failure to degrade proinflammatory cytokine mRNAs

An AUF1 knockout mouse is developed to understand the function of the AU-rich element (ARE)-binding protein AUF1. The results have provided the first in vivo evidence implicating AUF1 in regulation of the inflammatory response and they have provided a molecular understanding of AUF1 action in selective targeted degradation of inflammatory cytokine mRNAs.