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Hepatic gene expression profile of lipid metabolism in rats: impact of caloric restriction and growth hormone/insulin-like growth factor-1 suppression

Authors :
Higami, Yoshikazu
Tsuchiya, Tomoshi
Chiba, Takuya
Yamaza, Haruyoshi
Muraoka, Izumi
Hirose, Megumi
Komatsu, Toshimitsu
Shimokawa, Isao
Source :
The Journals of Gerontology, Series A. Nov, 2006, Vol. 61 Issue 11, p1099, 12 p.
Publication Year :
2006

Abstract

We investigated the role of the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis on caloric restriction (CR) using male wild-type and transgenic homozygous dwarf rats bearing an antisense GH transgene and their F1 heterozygous progeny fed either ad libitum or subjected to 30% CR. CR predominantly altered expression of hepatic genes involved in the stress response, xenobiotic metabolism, and lipid metabolism. Most gene expressions involved in stress response and xenobiotic metabolism were regulated in a GH/IGF-l-dependent manner, and those involved in lipid metabolism were regulated in a GH/IGF-l-independent manner. Moreover, CR enhanced the gene expression involved in fatty acid synthesis after feeding and those encoding mitochondrial [beta]-oxidation enzymes during food shortage, probably via transcriptional regulation by peroxisome proliferator-activated receptor [alpha]. These results, taken together with serum biochemical measures and hepatic triglyceride content, suggest that CR promotes lipid utilization through hepatic transcriptional alteration and prevents hepatic steatosis in a GH/IGF-1-independent manner.

Details

Language :
English
ISSN :
10795006
Volume :
61
Issue :
11
Database :
Gale General OneFile
Journal :
The Journals of Gerontology, Series A
Publication Type :
Academic Journal
Accession number :
edsgcl.157267710