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Antibodies with broad specificity to azaspiracids by use of synthetic haptens

Authors :
Forsyth, Craig J.
Jianyan Xu
Nguyen, Son T.
Samdal, Ingunn A.
Briggs, Lyn R.
Rundberget, Thomas
Sandvik, Morten
Miles, Christopher O.
Source :
Journal of the American Chemical Society. Nov 29, 2006, Vol. 128 Issue 47, p15114, 3 p.
Publication Year :
2006

Abstract

The successful detection of natural azaspiracids by antibodies raised against a synthetic hapten representing the common C28-C40 domain of the azaspiracids is reported. The advantages of applying synthetic organic chemistry to produce carefully designed haptens containing conserved substructures of complex toxin molecules are described.

Details

Language :
English
ISSN :
00027863
Volume :
128
Issue :
47
Database :
Gale General OneFile
Journal :
Journal of the American Chemical Society
Publication Type :
Academic Journal
Accession number :
edsgcl.157215578