Effects of PFT-α on cell survival and transactivation of known p53 responsive genes using rat liver cells and HepG2 cell line

Authors :: Farah, Ibrahim O.
Begum, Rowshan A.
Ishaque, Ali B.
Source :: Journal of the Mississippi Academy of Sciences. October 2006, Vol. 51 Issue 4, p232, 13 p.
Publication Year :: 2006
Abstract: ABSTRACT Pifithrin-α (PFT-α) is a reversible inhibitor of p53-mediated apoptosis, p53-dependent gene transcription, as well as down stream responsive gene function. In response to genotoxic agents, normal cells are instructed [...]

Subjects :: Gene mutations -- Research -- Physiological aspects
Liver cells -- Research -- Physiological aspects
Genetic research -- Physiological aspects
Cancer -- Genetic aspects
Rats as laboratory animals -- Research -- Physiological aspects
Science and technology
Physiological aspects
Research

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