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Fluvastatin reduces levels of plasma apo B-containing particles and increases those of LpA-I
- Source :
- American Journal of Medicine. June 6, 1994, Vol. 96 Issue 6A, p32S, 5 p.
- Publication Year :
- 1994
-
Abstract
- Epidemiologic studies have demonstrated an association between apolipoprotein (apo) B-containing particles (lipoprotein [Lp] E:B; LpC-III:B) and an inverse association between LpA-I and the risk of coronary artery disease (CAD). The effect of 6 weeks of treatment with fluvastatin (20 and 40 mg/day in the evening), a novel competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, on lipoparticle levels was studied in 423 patients with hypercholesterolemia after 14 weeks of standard dietary therapy. The combined data of the European double-blind controlled studies were used for the analysis. Two independent groups of hypercholesterolemia patients receiving fluvastatin (20 and 40 mg every evening) for 6 weeks were compared with a placebo group. For inclusion, patients had to fulfill the following criteria: plasma low-density lipoprotein (LDL) cholesterol levels >160 mg/dL and premature CAD and/or two associated risk factors; LDL cholesterol >190 mg/dL and no CAD; triglycerides
Details
- ISSN :
- 00029343
- Volume :
- 96
- Issue :
- 6A
- Database :
- Gale General OneFile
- Journal :
- American Journal of Medicine
- Publication Type :
- Periodical
- Accession number :
- edsgcl.15597698